Method and device for monitoring and treatment of seasonal affective disorder

ABSTRACT

This invention provides for an energized biomedical ophthalmic device and associated method of measuring changes in biomarkers contained in tear film to generate data related to a light therapy regimen used to treat symptoms associated with seasonal affective disorder. In some embodiments, the energized biomedical ophthalmic device can include an energized contact lens with a light source in communication with a processor controlling said light source according to the light therapy regimen. The light therapy regimen may be generated or modified by the processor from the measured changes and sometimes from user&#39;s preferences, and/or additional measurements, including for example, light exposure and/or circadian rhythm of the user.

FIELD OF USE

The present invention relates to devices and methods used to diagnoseand treat seasonal affective disorder (SAD). More specifically, toenergized biomedical ophthalmic devices capable of monitoring SADsymptoms for light therapy treatments.

BACKGROUND OF THE INVENTION

Seasonal affective disorder (SAD) is a well-established mood disorderwherein sufferers experience depressive symptoms in a certain season ofthe year, most frequently during the winter months. Those affected bySAD often have normal mental health during most of the year. Symptoms ofSAD may include, but are not limited to, excessive sleeping, lack ofenergy, craving carbohydrates, difficulty concentrating, and withdrawalfrom social activities. The symptoms result in feelings of depression,hopelessness, pessimism, and lack of pleasure.

Seasonal mood variations are believed to be related to changes inexposure to light. Individuals in geographic areas, such as the Arcticregion, that experience fewer daylight hours, lower sunlight intensity,or significant periods of overcast skies exhibit a greater incidence ofSAD. Variations in prevalence of SAD within the adult population areevident within the United States, ranging from low rates in Florida andother sunny states to notably higher rates in Alaska, New Hampshire andother northern or overcast areas.

Light therapy has been researched and established as a prominent andeffective treatment for classic, or winter-based, seasonal affectivedisorder. Conventional light therapy employs a device which emitssignificantly more lumens than a standard incandescent lamp. Commonimplementations include the preferred bright white full spectrum lightat 10,000 lux, or optionally blue light at a wavelength of 480 nm at2,500 lux, or green light at a wavelength of 500 nm at 350 lux. Lighttherapy normally requires a patient to sit with their eyes open at aprescribed distance from the light source for thirty to sixty minuteseach day. This seasonal treatment is maintained for several weeks untilthe patient experiences frequent exposure to natural light. A majorityof patients find the existing therapy inconvenient and a considerablepercentage, in some studies up to 19%, therefore stop the treatment. Newmethods and approaches are therefore desirable to deliver light therapyin more convenient, controlled, and intelligent manners.

SUMMARY OF THE INVENTION

The foregoing needs are met, to a great extent, by the presentinvention, wherein in one aspect it provides for an Energized BiomedicalOphthalmic Device capable of testing small volumes of tear fluid tomonitor and provide Intelligent Light Therapy to treat SAD. Included inthis description are a disclosure of a method to monitor SAD and deliverIntelligent Light Therapy accordingly, and an Energized BiomedicalOphthalmic Device with a biomarker sensor used to monitor SAD symptomsand in logical communication with a Light Source. In some embodiments,the Energized Biomedical Ophthalmic Device can be an EnergizedOphthalmic Lens comprising one or more sensor(s) and an integrated LightSource capable of treating SAD. In alternative embodiments, theEnergized Ophthalmic Lens can comprise one or more sensor(s) andcommunication means to transfer sensor measured data to a controller incommunication with a non-integrated Light Source capable of treatingSAD.

In some aspects of the present invention, a personalized dosing regimenof Light Therapy can be achieved. The personalized dosing regimen canresult in Intelligent Light Therapy when various data is analyzed tomake compensation to the Programmed Therapy Schedule. Data analyzed caninclude, but is not limited to, sensor measured data relating to changesin biomarkers in the tear film of the Energized Biomedical OphthalmicDevice user. Compensations can include shifting treatment frequencies,durations, and/or light intensities to provide more effective treatment,while taking into account user's preferences, to provide a more positiveexperience to the user.

In some embodiments, monitoring of biomarkers may be achieved throughone or more electrochemical sensor(s) with analytical sensitivity andcontained in the Biomedical Ophthalmic Device. The electrochemicalsensor(s) can analyze biomarkers in tear film including, for example,the presence and/or concentrations of symptom correlated biomolecules.Biomolecules interrelated to various symptoms of SAD can include but arenot limited to: Serotonin, Melatonin, and Interleukin-6 Analysis ofbiomolecules may occur at predetermined frequencies or times of the day,for example, every hour, or three hours, or during specific activities,or times of the day when the user is most susceptible to experience SADsymptoms. Other sensors that can help monitor SAD symptoms may also beincluded by some embodiments, including for example, light sensors, orsensors capable of sensing changes in the circadian rhythm of the user.

According to some embodiments, the sensors can be a microchip withelectrophoresis and selective chemoluminescence analytical sensitivitycapabilities. In some preferred sensors, the analytical sensitivity maybe achieved through an energized microchip component that can measureand data from the tear film biomolecules, for example, one or more of:electrical conductance, resistance or capacitance; changes influorescence, absorbance, light scatter or plasmon resonance, lightexposure, and circadian rhythm, to monitor, diagnose, and/or provideIntelligent Light Therapy to treat SAD.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 illustrates method steps that may be used to implement someaspects of the present invention.

FIG. 2 illustrates an exemplary energized biomedical ophthalmic devicewith a biomarker sensor that may be used in some lens embodiments of thepresent invention.

FIG. 3 illustrates an exemplary processor that may be used in someembodiments of the present invention.

FIG. 4 illustrates an energized biomedical ophthalmic device with anexemplary media insert including a microcontroller that may be used insome lens embodiments of the present invention.

FIG. 5 illustrates a cross section view of an exemplary energizedbiomedical ophthalmic device containing light sources according to somelens embodiments of the present invention.

FIG. 6 illustrates the back view of exemplary complementary eyeglasseswith light sources embedded in the lenses and with supportingelectronics that may be used with some embodiments of the presentinvention.

FIG. 7 illustrates a cross-section view of exemplary complementary eyeglasses with embedded light sources directing light into an energizedbiomedical ophthalmic device according to some contact lens embodimentsof the present invention.

FIG. 8 illustrates a cross-section view of exemplary complementaryeyeglasses with supporting electronics in wireless communication with anenergized biomedical ophthalmic device containing light sourcesaccording to some contact lens embodiments of the present invention.

FIG. 9A illustrates an energized biomedical ophthalmic device comprisingan exemplary coil type of antenna according to some ophthalmic lensembodiments of the present invention.

FIG. 9B illustrates an energized biomedical ophthalmic device comprisingan exemplary spiral type of antenna according to some contact lensembodiments of the present invention.

FIG. 9C is a block diagram representation of an antenna and receivercircuit in accordance to some embodiments of the present invention.

FIG. 10 is a schematic diagram of a processor that may be used toimplement some embodiments of the present invention.

DETAILED DESCRIPTION OF THE INVENTION

The present invention includes methods and an Energized BiomedicalOphthalmic Device for monitoring SAD symptoms and controlling lighttherapy used to treat SAD. In particular, the present invention includesmethods and device embodiments that are capable of monitoring biomarkersin tear film, and/or ocular surface conditions and characteristicscorrelated to symptoms of SAD to provide Intelligent Light Therapy.

In the following sections detailed descriptions of embodiments of theinvention will be given. The description of both preferred andalternative embodiments are exemplary embodiments only, and it isunderstood that to those skilled in the art variations, modificationsand alterations will be apparent. It is therefore to be understood thatsaid exemplary embodiments do not limit the scope of the underlyinginvention.

GLOSSARY

In this description directed to the present invention, various terms maybe used for which the following definitions may apply:

“Biomedical Ophthalmic Device” refers to any ophthalmic device that iscapable of residing in or on the eye. These devices can provide one ormore of: optical correction, therapy, and may be cosmetic. For example,the biomedical ophthalmic device can refer to an energized contact lens,intraocular lens, overlay lens, ocular insert, optical insert, punctalplug, or other similar ophthalmic device through which vision iscorrected or modified, an eye condition can be enhanced or prevented,and/or through which eye physiology is cosmetically enhanced (e.g., iriscolor). In some embodiments, the biomedical ophthalmic device of theinvention can include soft contact lenses made from silicone elastomersor hydrogels, which include but are not limited to silicone hydrogels,and fluorohydrogels.

“Component” as used herein refers to a device which draws electricalcurrent from an Energy Source to perform one or more of a change oflogical state or physical state.

“Energized” as used herein refers to the state of being able to supplyelectrical current to or to have electrical energy stored within.

“Energy Harvesters” as used herein refers to a device capable ofextracting energy from the environment and converting it to electricalenergy.

“Energy Source” as used herein refers to a device capable of supplyingEnergy or placing a biomedical device in an Energized state.

“Energy” as used herein refers to the capacity of a physical system todo work. Many uses within this invention may relate to the said capacitybeing able to perform electrical actions in doing work.

“Intelligent light therapy” as used herein may refer to a method ofdelivering light therapy whereby a processor evaluates various data and,based on data analysis, dynamically makes compensating adjustments to aprogrammed light therapy schedule and/or function. Intelligent lightTherapy can occur, for example, by adjusting light therapy based on oneor more conditions, including but not limited to, the user's exposure toambient light, measured biomarkers in tear film, and monitored circadianrhythm.

“Light Source” as used herein refers to a device capable of emittinglight.

“Light therapy” as used herein refers to exposure to specificwavelengths of light, controlled with various devices, and administeredfor a specified amount of time, at a specified intensity and, in somecases, at a specified time of day.

“Lithium Ion Cell” refers to an electrochemical cell where Lithium ionsmove through the cell to generate electrical energy. Thiselectrochemical cell, typically called a battery, may be reenergized orrecharged in its typical forms.

“Lux” as used herein refers to units of illumination in theInternational System of Units (SI). Lux provides a measure of luminouspower per area. One lux is the amount of illumination provided when onelumen is evenly distributed over an area of one square meter. This isalso equivalent to the illumination that would exist on a surface fromall points of which are one meter from a point source of oneinternational candle. One lux is equal to 0.0929 foot-candle.

“Optical Zone” as used herein refers to an area of an ophthalmic lensthrough which a wearer of the ophthalmic lens sees.

“Power” as used herein refers to work done or energy transferred perunit of time.

“Programmed light therapy schedule” as used herein refers to a set ofautomated instructions that controls light therapy timing, duration andintensity based on variables such as measured data, dates, geographicregion, and severity of a user's seasonal affective disorder symptoms. Aprogrammed light therapy schedule may be set by an eye careprofessional, a medical doctor, a software code incorporated in aprocessor, and/or a user.

“Rechargeable or Re-energizable” as used herein refers to a capabilityof being restored to a state with higher capacity to do work. Many useswithin this invention may relate to the capability of being restoredwith the ability to flow electrical current at a certain rate for acertain, reestablished time period.

“Reenergize or Recharge” as used herein refers to restoring to a statewith higher capacity to do work. Many uses within this invention mayrelate to a restoring device with the capability to flow electricalcurrent at a certain rate for a certain, reestablished time period.

“Seasonal Affective Disorder (SAD)” as used herein it may refer to arecurrent state of mood altering symptoms, usually experienced by peopledue to lack of sunlight, or light at certain wavelengths. It may includea mood disorder that occurs during seasons when exposure to sunlight islimited, characterized by symptoms of depression and relieved by thearrival of spring or by light therapy.

Humans' eyes, like other mammalian eyes, contain a fluid coating knownas tear fluid. Tear fluid can hydrate and lubricate the ocular surface,protect it, and generally provides an adequate environment for ocularhealth and vision. Like blood and saliva, components of tear fluidincluding some protein biomolecules can come from diverse sources andmay vary in concentrations according to physiological factors and/orenvironmental surrounding factors. The ability to measure biomolecules'characteristics, such as, concentrations, can provide helpfulinformation for identifying, correlating conditions and symptoms, and/ormonitoring optimum levels, for health management and intervention.

Protein biomolecules in tear fluid may be analyzed using methodsincluding electrophoresis, microfluidic chip based systems,spectrometry, and liquid chromatography. However, tear fluid collectionhas presented challenges including the collection of small volumes fortesting and preventing contamination in ways that are relativelyinnocuous to the individual, particularly due to the pronouncedsensitivity of most healthy eyes. The present invention provides formethods and Energized Biomedical Ophthalmic Devices that can analyzebiomolecules and, more specifically, biomolecules with identifiedproteins correlated to conditions or symptoms, also known as biomarkers.

Referring now to FIG. 1, method steps that may be used to monitor SADrelated symptoms are illustrated. At 101, one or more energizedBiomedical Ophthalmic Device(s) can be worn by an individual. Anenergized Biomedical Ophthalmic Device can reside in or on the eye. SomeBiomedical Ophthalmic Devices are preferably placed on the anteriorocular surface and may be used to provide one or more of: opticalcorrection, therapy, and may be cosmetic. For example, it may be anenergized ophthalmic lens or energized ophthalmic device, including butnot limited to a contact lens, intraocular lens, overlay lens, ocularinsert, optical insert, punctal plug, or other similar ophthalmic devicethrough which vision can be corrected or modified, an eye condition canbe enhanced or prevented, and/or through which eye physiology can beenhanced cosmetically.

In some aspects of the present invention, the Energized BiomedicalDevice may be used to monitor one or more SAD related symptoms.Monitoring of the symptoms may take place through the analysis ofbiomarkers in tear film through the use of sensors comprised by theEnergized Biomedical Ophthalmic Device. Additionally or alternatively,in some embodiments, it may also include measuring length and/orintensity of light received by the ophthalmic environment of the user120, and/or monitoring the circadian rhythm 125 of the user.

When analysis of biomarkers in tear film through the use of sensorstakes place 105, the biomarkers' changes can be correlated to known SADsymptoms 110. Examples of correlated symptoms of SAD may include, butare not limited to, excessive sleeping, lack of energy, cravingcarbohydrates, difficulty concentrating, and withdrawal from socialactivities. These symptoms can often result in feelings of depression,hopelessness, pessimism, and lack of pleasure which can be correlated tochanges in specific tear film biomarkers. Changes in biomarker of tearfilm can include, but are not limited to, variations in serotonin levelsand genetic polymosphisms, melatonin concentration changes signaling aphase change in circadian rhythm, and increased levels of Interleukin-6.

Known levels and thresholds of biomarkers concentrations in tear filmrelated to SAD may pre-programmed into a Component of the device usedfor the monitoring and, additionally or alternatively, the device maycontinue to learn from inputs and collected data particular to the user.In addition, because concentrations may vary with factors, such as, ageand environmental conditions, normal values measured in blood, serum orsaliva analytes of the individual, or of a comparable population, may becorrelated to tear film values of the user. The changes or determinedvalues then may be monitored 115 and light therapy based on the changesmay be provided to the user 130 when it is needed.

Referring now to FIG. 2, an exemplary energized biomedical ophthalmicdevice with a biomarker sensor Component 203 that may be used in someenergized ophthalmic lens 200 embodiments of the present invention isdepicted. In addition to the biomarker sensor Component 203, theexemplary energized ophthalmic lens 200 comprises an Energy Source 202and a Light Source 202A. The Energy Source 202 can be in electricalcommunication with a Light Source 202A and the Component 203. The LightSource 202A can include light-emitting diodes (LEDs) or other lightswhich emit blue light at wavelengths of 450 to 500 nanometers, mostpreferably at 470 to 480 nanometers, and at 2,000 to 3,000 lux.Alternatively, LEDs or other lights may emit green light at wavelengthsof 475 to 525 nanometers, most preferably at 490 to 510 nanometers, andat 300 to 400 lux. In another embodiment, a single Light Source may bepiped to one or more locations in an ophthalmic lens 201 to provide theillumination required for SAD light therapy.

The Component 203 can include any light sensor and/or electrochemicalsensor device with analytical sensitivity to detect changes inbiomarkers. The component may include a microchip with electrophoresisand selective chemoluminescence capabilities including, for example,capability to detect changes in fluorescence, absorbance, light scatteror plasmon resonance of tear film, light exposure, and circadian rhythm.In some embodiments, Component 203 can react to an electrical changewith a change in state and be, for example: a microchip such as asemiconductor type chip; a passive electrical device; an optical devicesuch as a crystal lens; a processor with a micro-electromechanicalmachine (MEMS), or a nano-electromechanical machine (NEMS).

Moreover, the Component 203 can include or be in logical connection withan electrical storage device such as a capacitor; ultracapacitor;supercapacitor; or other storage component. An Energy Source 202 caninclude, for example: a lithium ion battery located in the periphery ofan ophthalmic lens outside of the optic zone and be chargeable via oneor more of radio frequency; photo voltaics, and magnetic inductance intoan Energy Source 202.

As illustrated, in some embodiments, the Energy Source portion 202, theLight Source 202A, and the Component 203 can preferably be locatedoutside of an Optic Zone 204, wherein the Optic Zone 204 includes thatportion of the ophthalmic lens 200 providing a line of sight for anophthalmic lens 200 wearer. Other embodiments may include an EnergySource 202 in the optic zone portion of an ophthalmic lens. For example,such embodiments can include an Energy Source 202 of conductiveparticles too small to be viewable without aid to the human eye.

In some embodiments, a preferred ophthalmic lens type can include a lens201 that includes a silicone containing component. A“silicone-containing component” is one that contains at least one[—Si—O—] unit in a monomer, macromer or prepolymer. Preferably, thetotal Si and attached 0 are present in the silicone-containing componentin an amount greater than about 20 weight percent, and more preferablygreater than 30 weight percent of the total molecular weight of thesilicone-containing component. Useful silicone-containing componentspreferably comprise polymerizable functional groups such as acrylate,methacrylate, acrylamide, methacrylamide, vinyl, N-vinyl lactam,N-vinylamide, and styryl functional groups.

Referring now to FIG. 3, an exemplary processor that may be used in someEnergized Biomedical Ophthalmic Device embodiments of the presentinvention is illustrated at 300. In this illustration, the Energy Source310 may include a thin film, rechargeable lithium ion battery. Thebattery may have contact points 370 to allow for interconnection. Wiresmay be wire bond wires to the contact points 370 and connect the batteryto a photoelectric cell 360 which may be used to reenergize the batteryEnergy Source 310. Additional wires may connect the Energy Source to aflexible circuit interconnect via wire bonded contacts on a second setof contact points 350. These contact points 350 may be a portion of aflexible interconnect substrate 355 which may also include a LightSource 330.

The interconnect substrate may be formed into a shape approximating atypical lens conical form or other form depending on the BiomedicalOphthalmic Device. However to add additional flexibility needed in someembodiments, the interconnect substrate 355 may include additional shapefeatures such as radial cuts 345 along its length. Radial cuts may beused to form individual flap shaped structured of the interconnectsubstrate 355 and may be connected various electronic Components likeICs, discrete Components, passive Components and such devices which areshown as item 390. Components can be interconnected by wires or otherconnection means 340 to the conduction paths within the interconnectsubstrate 355. By way of non-limiting example, the various componentsmay be connected to the flexible interconnect substrate 355 by thevarious means of making interconnections to the battery. The combinationof the various electrical Components may define a control signal forcontrol of the biomarker monitoring, light source, and in someembodiments, for an electro-optical device shown as item 390. Thiscontrol signal may be conducted respectively along interconnect 320.

This type of exemplary energized ophthalmic lens with energizedfunctions is provided only for the purpose of example. In no way shouldthis description be construed to limit the scope of the inventive art asit will be apparent to one skilled in the art that many differentembodiments of function, design, interconnection scheme, energizationscheme and overall utilization of the concepts of this invention mayexist from this disclosure. For example, in some embodiments there maybe manners of affecting the ophthalmic lens' appearance. Aesthetics ofthe thin film microbattery surface may be altered in various mannerswhich demonstrate a particular appearance when embedded in theelectroactive contact lens or shaped hydrogel article. The thin filmmicrobattery may be produced with aesthetically pleasing patternedand/or colored packaging materials which could serve to either give amuted appearance of the thin film microbattery or alternatively provideiris-like colored patterns, solid and/or mixed color patterns,reflective designs, iridescent designs, metallic designs, or potentiallyany other artistic design or pattern. In other embodiments, the thinfilm battery may be partially obscured by other Components within thelens, for example, a photovoltaic chip mounted to the battery anteriorsurface, or alternatively, by placement of the battery behind all or aportion of a flexible circuit. In further embodiments, the thin filmbattery may be strategically located such that either the upper or lowereyelid partially or wholly obscures the visibility of the battery.

In preferred embodiments, the Energy Source and Light Source may notobstruct the transmission of light through the ophthalmic lens.Consequently, designs can be so that the Optical Zone, central 5-8 mm,of the energized lens may not be significantly obstructed by any opaqueportions of the Energy Source and Light Source. There may be manydifferent embodiments relating to the design of various Energy Sourcesand Light Sources to interact favorably with the optically relevantportions of an energized ophthalmic lens.

According to some aspects of the present invention, the Energy Sourceand Light Source should be placed at a certain distance from the outeredge of the contact lens to enable advantageous design of the contactlens edge profile in order to provide good comfort while minimizingoccurrence of adverse events. Examples of such adverse events to beavoided may include superior epithelial arcuate lesions or giantpapillary conjunctivitis.

In some embodiments, a cathode, electrolyte and anode features ofembedded electrochemical cells can be included and be formed, forexample, by printing appropriate inks in shapes to define such cathode,electrolyte and anode regions. It may be apparent that batteries thusformed could include both single use cells, based for example onmanganese oxide and zinc chemistries, and rechargeable thin batteriesbased on lithium chemistry thin film battery chemistry. It can also beapparent to one skilled in the art that a variety of differentembodiments of the various features and methods of forming EnergizedBiomedical Ophthalmic Devices may involve the use of printingtechniques.

Referring now to FIG. 4, a cross section of an Energized BiomedicalOphthalmic Device 400 with an exemplary media insert 401 including amicrocontroller 404 that may be used in some lens embodiments of thepresent invention is depicted. An activator or processor 405 can be usedto implement one or more executable programs included within memorystorage in the Microcontroller 404. Programs can be operative to controla light source (not shown) in logical communication with theMicrocontroller. One or more Light Source may be included in the mediainsert, outside the media insert in/on the biomedical ophthalmic device,or in proximity thereto; for example, in complementary spectacles(further described in FIG. 6). Additionally, in some embodiments, aprogram executed via the Microcontroller 404 can cause a change of statein a Component 403. The memory storage can include a random accessmemory semiconductor; a read only memory semiconductor; a static memory;an erasable programmable read only memory; or other component capable ofstoring digital data and providing the data on command.

An Energy Harvester, such as a photoreceptor 402 can be included forrecharging an Energy Source 408, such as a lithium based battery or acapacitor. The microcontroller 404 can be used to manage a Re-energizingprocess. For example, the processor 405 can receive data indicative ofan amount of charge present in an energy source 408 and open a circuitallowing current to flow from an Energy Harvester 402, for example, aphotoreceptor to the Energy Source 408 (other examples can include amagnetic or inductive device). In another aspect, the processor can alsobe programmed to monitor when the Energy Harvester 402 can be capable ofproviding sufficient current to charge an Energy Source 408 and providean electrical pathway via circuitry suitable for such charging.Electrical circuitry for charging can include, for example, transistorsacting as switches and diodes for ensuring a proper direction of currentflow.

Referring now to FIG. 5, a cross section view of an exemplary energizedbiomedical ophthalmic device 500 containing light sources 502 accordingto some lens embodiments of the present invention is depicted. In thepresent example, the exemplary energized ophthalmic lens 501 is acontact lens and is depicted directing light 503 onto the cornea 504 ofan eye 505. In some embodiments, a cross-section view 500 may be atop-down view, wherein one or more embedded Light Sources 502 are placednear the sides of a contact lens 501. In other embodiments, across-section view 500 may be a side view, such that one or moreembedded Light Sources 502 are placed near the top and bottom of acontact lens 501. A number of Light Sources 502 and an arrangement ofLight Sources 502 around a perimeter of a contact lens 501 may vary. ALight Source 502 directs illumination toward a wearer's eye such thatillumination may not be obvious to an observer. A contact lens 501 mayalso include a coating which shields light therapy luminescence frombeing readily noticed by an observer to not diminish a user's LightTherapy.

Embedded Light Sources 502 can include light-emitting diodes (LEDs) orother Light Sources 502 capable of emitting light 1003 for LightTherapy. Light Sources 502 may include light-emitting diodes (LEDs) orother lights which emit blue light at wavelengths of 450 to 500nanometers, most preferably at 470 to 480 nanometers, and at 2,000 to3,000 lux. Alternatively, LEDs or other lights may emit green light atwavelengths of 475 to 525 nanometers, most preferably at 490 to 510nanometers, and at 300 to 400 lux. Another embodiment includes a singleLight Source from which light may be piped to one or more locationswithin an ophthalmic lens 501 to provide illumination.

The exemplary ophthalmic lens 501 includes supporting electronics, notillustrated in this figure, with Components such as light sensors,biomarker sensors, Energy Source, capacitors, memory, processor, andcommunication device. Light sensors are used to detect ambient whitelight, blue light or green light. An Energy Source and capacitors cansupply energy to other Components of an Energized Biomedical OphthalmicDevice. Memory may be used, by way of non-limiting example, to storepre-programmed Light Therapy Schedules, to store data collected from oneor more sensors, to store user's preferences, to store actual LightTherapy dates, times, durations and intensities, and to store datarelated to a Light Source and light sensor operation in order to detectdevice failures. Moreover, a processor may be used, for example, to runprogrammed Light Therapy Schedules stored in memory, to analyze lightsensor data and determine a unique personalized Light Therapy Schedulebased on the wearer's exposure to ambient light, to evaluate manualchanges to a programmed Light Therapy schedule and provide compensatingadjustments, i.e., Intelligent Light Therapy, and to analyze lightsource and light sensor data to detect device failures.

A communication device may be used to electronically control one or moreof: the transfer of digital data to and from an energized biomedicalophthalmic device and external devices, and the transfer of digital databetween components within the energized biomedical ophthalmic device.The communication device may be used to wirelessly communicate with oneor more external devices including, by way of non-limiting examples, afob, a personal digital assistant (PDA), or a smartphone applicationused to control the Energized Biomedical Ophthalmic Device. WithinEnergized Biomedical Ophthalmic Devices, communication betweenComponents may be via physical connection, such as via a directconductive path, or may be wireless. Communication between internalcomponents may include, for example, control of a Light Source from aprocessor and data transfer between sensors and memory.

Supporting electronics are in logical and electrical communication withLight Sources 502 contained within the energized biomedical ophthalmicdevice including, for example, a contact lens 501. Communication may bevia a direct conductive path between supporting electronics and LightSources 502 or via wireless communication. Wireless modes ofcommunication may include, for example, inductance accomplished via anantenna located proximate to a Light Source 502 in the contact lens 501and a power source transmitting power from another area within thecontact lens 501 to the antenna.

In some embodiments, supporting electronics may be included in a fob,jewelry, hat, clothing, or other items worn by a user such that sensors,such as light sensors, detect ambient light experienced by the user andsupporting electronics are near a contact lens for purposes of wirelesscommunication. Wireless modes of communication can include, for example,inductance. Inductance may be accomplished via an antenna located in/onthe energized biomedical ophthalmic device and a power sourcetransmitting power from supporting electronics in jewelry, clothing, orother item proximate to the antenna.

In some embodiments, a user may adjust timing, duration and intensity oflight therapy using an external device, including but not limited to oneor more of: a fob, a personal digital assistant, computer, tablet, and aSmartphone application. Some embodiments provide for a basic operationalstate, wherein Light Therapy is controlled manually by a user startingand stopping therapy at appropriate times.

According to the present embodiment, a programmed Light Therapy Schedulemay, for example, automatically adjust light therapy timing, durationand intensity based on variables such as, dates, geographic region,user's preferences, and biomarkers sensor collected data correlated toSAD symptoms and the severity of a user's SAD symptoms. A ProgrammedLight Therapy Schedule may be set by an eye care professional, a medicaldoctor, or a user. In some embodiments, the light therapy schedule maylearn from past responses and adjust to provide Intelligent LightTherapy. For example, an response during programmed light therapy caninclude, a user adjusting light intensity based on an activity, such as,for example, decreasing light intensity when reading, working on acomputer, or driving. Conversely, it may be desirable to increase lightintensity during work breaks, lunch break, or other less visually activetimes. Accordingly, in some embodiments Intelligent Light Therapy can bedelivered when a processor evaluates manual changes and detected userchanges of a programmed Light Therapy Schedule and provides compensatingadjustments in duration, frequencies and/or intensity of treatment.Intelligent Light Therapy can also be achieved when data from lightsensors is analyzed by a processor and a programmed Light TherapySchedule is dynamically adjusted based on a wearer's exposure to ambientlight.

In another embodiment of the present invention, a user may manuallyadjust light therapy based on the results of tear fluid measured data,and/or blood, saliva testing including but not limited to testing forconcentration of one or more of: melatonin, serotonin and interleukin-6levels. Concentration of biomarkers can increase or decrease based onlight exposure or a SAD symptom. For example, melatonin levels areinhibited by light and increase with darkness. Higher levels ofmelatonin promote sleepiness and lethargy, symptoms of seasonalaffective disorder.

In still other embodiments, as part of an user's preferences, a user maymanually adjust light therapy to intentionally alter their sleep cycle.The use of light therapy for sleep cycle alteration may be valuable forpersons working night shifts, for persons travelling to significantlydifferent time zones, for military personnel preparing for nightoperations, and other uses. Similarly, Light Therapy initiated by theuser upon awakening may be used to treat circadian rhythm disorders suchas delayed sleep phase syndrome (DSPS) and non-24-hour sleep-wakesyndrome.

Referring now to FIG. 6, the back view of exemplary eyeglasses 600 withlight sources 602 embedded in the lenses 603 and with supportingelectronics is depicted. In other embodiments, Light Sources 602 mayalso be mounted on the surface of lenses 603. Light Sources 602 mayinclude light-emitting diodes (LEDs) or other lights which emit bluelight at wavelengths of 450 to 500 nanometers, most preferably at 470 to480 nanometers, and at 2,000 to 3,000 lux. Alternatively, LEDs or otherlights may emit green light at wavelengths of 475 to 525 nanometers,most preferably at 490 to 510 nanometers, and at 300 to 400 lux. In yetanother embodiment, a single light source may be piped to one or morelocations within an eyeglass lens 603 or eyeglass frame 601 to provideillumination. Light pipes may include, for example, fiber opticpathways.

An example of illuminated light sources is illustrated at 604. A lightsource 602 provides illumination toward a wearer's eyes such that anillumination is not obvious to an observer.

Light Sources 602 can be connected to one another via conductive paths605. Conductive paths 605 may be wires embedded within a lens 603 or maybe a conductive material including, for example, gold, copper, silver orother metal or conductive fiber applied to a surface of a lens 603 viapad printing, sputter coating, vapor deposition or another suitablemethod. Conductive paths 605 can be in electrical and logicalcommunication with supporting electronics contained within one or bothtemple pieces 609. In some embodiments, supporting electronics areminiaturized such that they may be contained in other areas ofeyeglasses such as in areas near a hinge 607, within a frame above alens 608, within a bridge 610, within an earpiece 611, or other area.

One or more light sensors 606 can be used to detect ambient white light,blue light or green light. Light sensors 606 may be located within aneyeglass frame 601 near a hinge 607, within a frame above a lens 608,within a temple piece 609, within a bridge 610, or other appropriatearea where a sensor 606 will not be obstructed, for example, by hair. Alight sensor 606 is in electrical and logical communication withsupporting electronics contained within one or both temple pieces 609 orother area of eyeglasses.

In some embodiments, a user control element 612, such as a switch orbutton, can be provided to allow a user to adjust timing, duration andintensity of light therapy. One or more user control elements 612 may bepresent in temple pieces 609 or other areas of eyeglasses including, forexample, in areas near a hinge 607, within a frame above a lens 608,within a bridge 610, within an earpiece 611, or other area.

Referring now to FIG. 7, a cross-section view 700 of exemplary eyeglasses 701 with embedded light sources 702 directing light into acomplementary energized biomedical ophthalmic device 705 according tosome contact lens embodiments of the present invention is depicted.Cross-section view 700 includes an eyeglass lens 701 with embedded lightsources 702 directing light 703 into light scattering areas 704 of acomplimentary contact lens 705. A light scattering area 704 can resultin light 706 being dispersed across a cornea 707 of an eye 708. A lightscattering area 704 may include diffractive properties, refractiveproperties, reflective properties or any combination of diffractive,refractive and reflective properties.

In some embodiments, a cross-section view 700 may be a top-down view,wherein one or more embedded light sources 702 are placed near the sidesof an eyeglass lens 701. In other embodiments, a cross-section view 700may be a side view, such that one or more embedded light sources 702 areplaced near the top and bottom of an eyeglass lens 701. In still otherembodiments, embedded light sources 702 may be embedded in or mounted onan eyeglass frame rather than an eyeglass lens 701.

Embedded light sources 702 can include, for example, the light-emittingdiodes (LEDs) or other light sources 702 previously described herein.Supporting electronics (not shown) can be contained in an eyeglass frameand in the energized biomedical ophthalmic device and be incommunication with each other. For example, for the biomarker sensor ofthe energized biomedical ophthalmic device to send collected biomarkerconcentration data to a communication Component of the eyeglasses.Supporting electronics can be Components located in one or thecomplementary devices of both, and may include components including, forexample, light sensors, batteries, capacitors, memory, processors, and aUSB connector. Moreover, supporting electronics are in logical andelectrical communication with light sources 702 and biomarker sensors(not depicted). Electrical communication may be provided, for example,via a conductive contact between a source located in a temple of a pairof eyeglasses, via a conductive wire, a conductive ribbon wire, or viawireless modes, such as inductance. Inductance may be accomplished, forexample, between an antenna located in the eyeglasses and complementarylens.

In some embodiments, light scattering areas 704 of a complimentarycontact lens 705 form a ring within a perimeter area of a complimentarycontact lens 705 such that directed light 703 need not strike a limitedtarget area. The orientation of a complimentary contact lens 705 on aneye 708 relative to light sources 702 within an eyeglass lens 701 istherefore inconsequential when light 703 is directed toward a lightscattering area 704 continuously present around a perimeter area of acomplimentary contact lens 705.

In some preferred embodiments, a complimentary contact lens 705 mayinclude an internal barrier between a light scattering area 704 and anOptical Zone in a central portion of a lens. An internal barrierprevents light 703 intended for light therapy from being dispersed intoan Optical Zone of a complimentary contact lens 705. This way, light 703intended for Light Therapy is only dispersed around a perimeter of acornea 707, minimizing its effect on normal vision.

In still other embodiments, an entire complimentary contact lens 705includes light scattering properties such as diffraction, refraction andreflection. Light scattering properties are designed such that theydisperse only light 703 of wavelengths emitted by embedded light sources702. This embodiment supports maximum dispersion of light 703wavelengths intended for Light Therapy within an eye 708 while notcausing dispersion of light wavelengths that would affect normal vision.

Referring now to FIG. 8, a cross-section view 800 of exemplary eyeglasses 801 with supporting electronics 802 in wireless communicationwith an energized biomedical ophthalmic device 805 containing lightsources 804 according to some contact lens embodiments of the presentinvention is depicted. Cross-section view 800 includes an eyeglass frame801 containing supporting electronics 802. Supporting electronics 802may include Components such as light sensors, batteries, capacitors,memory, processors, and a USB connector. Supporting electronics 802 arein wireless communication 803 with a complimentary contact lens 805containing embedded Light Sources 804 directing light 806 onto a cornea807 of an eye 808. Supporting electronics 802 may be placed in variouslocations embedded in or mounted on an eyeglass frame 801.

In other embodiments, supporting electronics 802 may be included injewelry, hats, clothing, or other items worn by a user such that lightsensors detect ambient light experienced by the user and supportingelectronics 802 are near a complimentary contact lens 805 for purposesof wireless communication. Wireless modes of communication may include,for example, inductance. Inductance may be accomplished via an antennalocated in a complimentary contact lens 805 and a power sourcetransmitting power from an eyeglass frame 801, jewelry, clothing, orother item proximate to the antenna.

In some embodiments of the present invention, a cross-section view 800may be a top-down view, wherein supporting electronics 802 are placednear the sides of an eyeglass frame 801. In other embodiments, across-section view 800 may be a side view, such that supportingelectronics 802 are placed near the top and bottom of a side of aneyeglass frame 801. A number of embedded light sources 804 and anarrangement of embedded light sources 804 around a perimeter of acomplimentary contact lens 805 may vary. Embedded light sources 804include previously described light-emitting diodes (LEDs) or other lightsources 804 emitting light 806 for light therapy.

In some embodiments, Light Sources 804 may direct light 806 into aninterior portion of a complimentary contact lens 805 in which the LightSources 804 can be embedded or positioned onto a surface of the contactlens. Light 806 may be directed into a light scattering area, notdepicted, including diffractive properties, refractive properties,reflective properties, or any combination of diffractive, refractive andreflective properties. A light scattering area may form a ring within aperimeter area of a complimentary contact lens 805. Light 806 striking alight scattering area causes a generally broad dispersion of light 806onto a cornea 807 of an eye 808.

In some preferred embodiments, a complimentary contact lens 805 may alsoinclude an internal barrier between a light scattering area around aperimeter of a lens and an optical zone in a central portion of a lens,and light scattering properties as previously described.

Antennas or antenna systems may serve as a means for receiving signals,as a means for transmitting signals, as an inductive coupling means, orany combination thereof. The function of an antenna determines itsdesign as well as its supporting circuitry. For example, an antenna maybe coupled to a receiver unit, a transmitter circuit, an inductivecoupling circuit or to any combination thereof. Basically, an antenna isan electrical device that converts electromagnetic waveforms, orelectrical signals into different electrical signals. The discussion ofFIG. 9A and FIG. 9B focuses on exemplary assemblies that compriseantenna systems and FIG. 9C represents a block diagram of an antenna andreceiver circuit in accordance to the exemplary assemblies of FIGS. 9Aand 9B.

Referring now to FIG. 9A, an exemplary antenna system according to someembodiments of the present invention is depicted. Circuit board 904Athat may be utilized with one or more Component of the energizedbiomedical ophthalmic device, such as the biomarker sensor, Light Sourceand/or an optical lens assembly of an ophthalmic lens. Circuit board904A comprises both top side conductive interconnect traces 912A1 andbottom side conductive interconnected traces 912A2 (shown in phantom),through-holes or vias 918A for making electrical connections between thetop and bottom sides, mounting pads 914A, a center opening 916A, and oneor more spiral antenna structures 920A. However, in some embodiments, asingle loop antenna may be appropriate. Each of the one or more spiralantenna structures 920A can comprise one or more turns of wire,conductive traces or the like formed in either or both of the top sideor the bottom side of the circuit board 904A. If multiple antennas areutilized on opposite sides, the through-hole or vias 908A may beutilized to make connections therebetween.

It will be appreciated that the circuit board 904A may compriseadditional metal layers and that any combination of layers may be usedto construct the spiral antenna structures 920A. The antenna structuresalternately may be embedded on an inner conducting layer, with otherconducting layers above and/or below the antenna structures 920A.

Referring now to FIG. 9B, another exemplary antenna system according tosome embodiments of the present invention is depicted. Like the previousexample, circuit board 904A that may be utilized with one or moreComponent of the Energized Biomedical Ophthalmic Device, such as thebiomarker sensor, Light Source and/or an optical lens assembly of anophthalmic lens. Circuit board 904B comprises both top side conductiveinterconnect traces 912B1 and bottom side conductive interconnectedtraces 912B2 (shown in phantom), through-holes or vias 918B for makingelectrical connections between the top and bottom sides, mounting pads914B, a center opening 916B, and a multi-turn loop antenna 920B.However, in some embodiments a single loop antenna may be appropriate.The multi-loop antenna 920B comprises two or more turns of wire,conductive traces or the like formed in either or both of the top sideor the bottom side of the circuit board 904B. If multiple antennas areutilized on opposite sides, the through-hole or vias 908B may beutilized to make connections therebetween. It will be appreciated thatthe circuit board 904B may comprise additional metal layers and that anycombination of layers may be used to construct the multi-turn loopantenna 920B.

Before the description of an exemplary block diagram of an antenna andreceiver circuit, it is important to note that the circuits set forthand described subsequently may be implemented in a number of ways. Inone exemplary embodiment, the circuits may be implements using discreteanalog components. In another exemplary embodiment, the circuits may beimplemented in integrated circuits or a combination of integratedcircuits and discrete components. In yet another alternate exemplaryembodiment, the circuits or particular functions may be implemented viasoftware running on a microprocessor or microcontroller.

Referring now to FIG. 9C, a block diagram representation of an antennaand receiver circuit in accordance to some embodiments of the presentinvention is illustrated. The radio receiver electronic circuit 900C cancomprise an antenna match circuit 904C, a receiver circuit 906C, acontroller 908C, an actuator 910C, a battery 912C and a power managementcircuit 914C. In this exemplary configuration, the antenna 904C can beadapted to receive an electromagnetic signal 901C and to provide areceived electrical signal to the antenna match circuit 904C. Theantenna match circuit 904C may comprise any suitable circuitry necessaryfor balancing the impedance between the source and the load to maximizepower transfer and/or minimize reflection from the load. Essentially,antenna impedance is the ratio of voltage to current at any point on theantenna and for efficient operation, the antenna impendence should bematched to the load, and thus a match circuit is utilized.

Accordingly, the match circuit 904C can be adopted to provide animpedance match between the antenna 902C and the receiver circuit 906Cfor an optimum power match, noise match or other match condition as isknown in the radio and circuit design arts. The receiver circuit 906Ccan comprise any suitable circuitry necessary to process the modulatedsignal received by the antenna 902C and provide a demodulated signal tothe controller 908C. For purposes of clarity, modulation involvesvarying one or more properties of a signal or electromagnetic waveform.For example, a waveform may be amplitude (AM), frequency modulated (FM)or phase modulated (PM). Other forms of analog as well as digitalmodulation can also be implemented in some embodiments.

Demodulation, on the other hand, can include extracting the originalinformation bearing signal from the modulated carrier wave. It is thisdemodulated information signal that can provide instructions to thecontroller 908C. The controller 908C in turn can provide a controlsignal to the actuator 910C based upon the demodulated signal in orderto control a state or operation of the actuator 910C. The control signalmay be further based on any internal state of the controller, forexample, to implement control laws, and/or any other circuits coupled tothe controller, for example, to implement a feedback control system orto modify the actuator operation based on other information such asinformation based upon sensor data.

The battery 912C provides a source of electrical energy for Componentsin the electronic circuit 900C requiring energy. The power managementcircuit 914C can be adapted to receive a current from the battery 912Cand condition it or regulate it to provide a workable output voltagesuitable for use by the other active circuits in the electronic circuit900C. The controller 908C may also be utilized to control the receivercircuit 906 or other circuits in the receiver 900C. The antenna 902C maycomprise, for example, one or more of the configurations previouslydescribed. Other embodiments may include single turn loop antenna, amulti-turn loop antenna, a spiral antenna, a coil antenna subassembly, astacked die configuration or arrangement or a suitable combinationthereof.

As is known in the relevant art, a preferred method for the transfer ofpower between an antenna and a receiving and/or transmitting circuit mayrequire matching the impedance presented and/or transmitting circuitrequires matching the impedance presented to the antenna and theimpedance presented to the circuit. Essentially, suitable power transfercan occur when the reactive components of the antenna and circuitimpedance are cancelled and the resistive components of the impedancesare equal. A matching circuit may be introduced to couple the antenna tothe circuit that meets the optimum power transfer criterion at each,thereby allowing for optimum power transfer to occur between the antennaand circuit. Alternatively, a different criterion may be selected tooptimize a different parameter such as maximum current or voltage at thecircuit. Matching circuits are well known in the art and may beimplemented with discrete circuit component such as capacitors,inductors and resistors, or with conductive structures such as traces ina circuit board, that provide a desired impendence characteristic.

Impedances of small RF loop antennas are typically between 20 and 50nanohenries, and matching component valves can be in the range of 0.5 to10 picofarads for capacitors and 3 to 50 nanohenries for inductors.Impedances of inductive charging coils are typically between 100nanohenries and 5 nanohenries and associated capacitors for resonatingthe circuits are between 20 and 100 picoforads.

The actuator 910C may comprise any number of suitable devices. Forexample, the actuator 910C may comprise any type of electromechanicaldevice, for example, a pump or transducer. The actuator may alsocomprise an electrical device, a chemical release device or anycombination thereof. The actuator 910C may be replaced or include acontrolled device, for example, a Light Source used to deliver LightTherapy, or diode array or any other suitable display, or userinterface.

The battery 912C may comprise any suitable device for the storage ofelectrical energy as previously described. In alternate exemplaryembodiments, no battery may be required as explained above with respectto RF energy harvesting or near field inductive coupling. Alternatively,mechanical vibration and similar means may be utilized to generate orharvest power.

The power management circuit 914C may comprise additional circuitry fora wide variety of functions in addition to regulating the output of thebattery 912C. For example, the power management circuit 914C maycomprise circuitry for monitoring various battery parameters such ascharge, preventing overdischarge of the battery, and/or supervising thestartup and shut down of the electronic circuit 900C.

Referring now to FIG. 10, the block diagram of a controller 1000 thatmay be used to implement some embodiments of the present invention isdepicted. The controller 1000 includes a processor 1010, which mayinclude one or more processor components coupled to a communicationdevice 1020. In some embodiments, a controller 1000 can be used totransmit energy to an Energy Source, sensor, and/or Light Source placedin an energized biomedical ophthalmic device.

The controller can include one or more processors, coupled to acommunication device configured to communicate energy via acommunication channel. The communication device may be used toelectronically control the transfer of digital data to and from anophthalmic device and/or control of a Light Source or other componentincorporated into the ophthalmic lens.

The communication device 1020 may also be used to communicate, forexample, with one or more controller apparatus or manufacturingequipment components. The processor 1010 is also in communication with astorage device 1030. The storage device 1030 may comprise anyappropriate information storage device, including combinations ofmagnetic storage devices, optical storage devices, and/or semiconductormemory devices such as Random Access Memory (RAM) devices and Read OnlyMemory (ROM) devices.

The storage device 1030 can store a program 1040 for controlling theprocessor 1010. The processor 1010 performs instructions of the program1040, and thereby operates in accordance with the present invention. Thestorage device 1030 can also store data, such as, ophthalmic data,geographic data, sensor data, and related data in one or more databases.The database may include customized Energy Source and Light Sourcedesigns, and specific control sequences for controlling energy to andfrom an Energy Source, sensor, and a Light Source.

CONCLUSION

A number of embodiments of the present invention have been described.While this specification contains many specific implementation details,there should not be construed as limitations on the scope of anyinventions or of what may be claimed, but rather as descriptions offeatures specific to particular apparatus embodiments of the presentinvention.

Certain apparatus and Lens features that are described in thisspecification in the context of separate embodiments can also beimplemented in combination in a single embodiment. Conversely, variousfeatures that are described in the context of a single embodiment canalso be implemented in combination in multiple embodiments separately orin any suitable subcombination. Moreover, although features may bedescribed above as acting in certain combinations and even initiallyclaimed as such, one or more features from a claimed combination can insome cases be excised from the combination, and the claimed combinationmay be directed to a subcombination or variation of a subcombination.

Similarly, while method steps are depicted in the drawings in aparticular order, this should not be understood as requiring that suchmethod steps be performed in the particular order shown or in sequentialorder, or that all illustrated operations be performed, to achievedesirable results. In certain circumstances, multitasking and parallelmay be advantageous. Moreover, the separation of various apparatuscomponents in the embodiments described above should not be understoodas requiring such separation in all embodiments, and it should beunderstood that the described apparatus components and method steps cangenerally be integrated together in a single apparatus or method or usedin multiple apparatus or methods.

Thus, particular embodiments of the subject matter have been described.Other embodiments are within the scope of the following claims. In somecases, the method steps recited in the claims can be performed in adifferent order and still achieve desirable results. In addition, theprocesses depicted in the accompanying figures do not necessarilyrequire the particular order show, or sequential order, to achievedesirable results. Nevertheless, it will be understood that variousmodifications may be made without departing from the spirit and scope ofthe claimed invention.

1. A method of monitoring and treating seasonal affective disordersymptoms of an individual, the method comprising: wearing an energizedbiomedical ophthalmic device; measuring changes in tear film biomarkers;correlating the measured changes in tear film biomarkers to associatedsymptoms of seasonal affective disorder; generating data from themeasured changes related to a light therapy used to treat seasonalaffective disorder symptoms; and implementing generated data into alight therapy regimen.
 2. The method of claim 1, additionally comprisingthe step of creating an intelligent light therapy schedule according tothe light therapy regimen and compensating adjustments made based on oneor more conditions or settings specific to the individual.
 3. The methodof claim 1, additionally comprising the step of monitoring lightexposure and light intensity the individual's ocular environment isexposed to over a period of time.
 4. The method of claim 1, additionallycomprising the step of monitoring the circadian rhythm of theindividual.
 5. The method of claim 1, additionally comprising the stepof gathering individual's preferences to generate data related to thelight therapy used to treat seasonal affective disorder.
 6. The methodof claim 1, wherein the biomarkers include serotonin.
 7. The method ofclaim 1, wherein the biomarkers include melatonin.
 8. The method ofclaim 1, wherein the biomarkers include interleukin-6.
 9. An energizedbiomedical ophthalmic device comprising: an energy source; a lightsource energized by the energy source; a biomarker sensor, wherein thebiomarker sensor can detect changes in biomolecules contained in thetear film of a user and generate signal data corresponding to themeasured changes; a processor in logical communication with thebiomarker sensor, wherein the processor operative to receive and processsaid signal data to output data related to the control of the lightsource; and wherein the light source is controlled by and in proximityto the processor.
 10. The energized biomedical ophthalmic device ofclaim 9, additionally comprising a light sensor in communication withthe processor.
 11. The energized biomedical ophthalmic device of claim9, wherein the biomarker sensor comprises an electrochemical microchipwith analytical sensitivity.
 12. The energized biomedical ophthalmicdevice of claim 11, wherein the electrochemical microchip withanalytical sensitivity is capable of measuring changes of melatoninbiomolecules in tear film.
 13. The energized biomedical ophthalmicdevice of claim 11, wherein the electrochemical microchip withanalytical sensitivity is capable of measuring changes of serotoninbiomolecules in tear film.
 14. The energized biomedical ophthalmicdevice of claim 11, wherein the electrochemical microchip withanalytical sensitivity is capable of measuring changes of interleukin-6biomolecules in tear film.
 15. The energized biomedical ophthalmicdevice of claim 9, wherein the energized biomedical ophthalmic devicecomprises an energized contact lens.
 16. The energized biomedicalophthalmic device claim 15, wherein the energized contact lens comprisesa media insert encapsulating the energy source.
 17. The energizedbiomedical ophthalmic device claim 9, additionally comprising anantenna.
 18. The energized biomedical ophthalmic device claim 17,wherein the antenna can transmit electrical signals from an exteriorcontroller.
 19. The energized biomedical ophthalmic device of claim 9,comprising an energized complementary contact lens comprising theprocessor in logical communication with a second processor contained inspectacles.
 20. The energized biomedical ophthalmic device claim 9,wherein the light source comprises one or more light-emitting diodes.